Rapoport JL, Berg CJ, Allergen cross-contamination DR, et al: Sgimulant effects of caffeine in children. Phosphodiesterase inhibitors. At a high dose, caffeine shows a euphoric effect.

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Its popularity in the US is growing because of its antioxidant properties, and it is commonly found in grocery stores, pharmacies, and beverage chains such as Starbucks. Green tea is consumed to reduce the risk of various malignancies, such as colon, gastric, and renal cancer; to treat gastrointestinal disorders, headaches, and mental fatigue; to prevent cavities; as a diuretic; and to lose weight.

The active ingredients of green tea include caffeine, 2-amino N-ethylcarboxyamido -pentanoic acid, catechins, and polyphenolic compounds. Epicatechin derivatives from green tea interact with hepatic cytochrome P and inhibit the Pdependent mixed-function oxidase enzymes in skin and liver. In vitro studies show green tea to be antibacterial, antimutagenic, and anticarcinogenic.

Green tea is marketed as a weight loss product. In a placebo-controlled trial, 10 healthy men were randomly assigned to receive either green tea extract, caffeine, or placebo.

Green tea had thermogenic properties and promoted fat oxidation beyond that explained by its caffeine content. Green tea extract may play a role in the control of body composition via sympathetic activation of thermogenesis, fat oxidation, or both. Green tea can cause gastrointestinal upset and constipation, as well as the common side effects and drug interactions associated with caffeine.

It may interact with anticoagulants due to its antiplatelet effects. Caffeine withdrawal symptoms may occur after green tea has been consumed for longer than two weeks.

No long-term studies exist on the safety of green tea during lactation and pregnancy. As with any caffeine product, excessive consumption should be avoided in pregnant or breastfeeding women; in those with cardiac arrhythmias, hypertension, gastrointestinal ulcers, anxiety, or renal disease; and in those taking antifungal medications or aminophylline.

Use is precautionary in infants and young children. A retrospective trial noted that microcytic anemia can occur in infants who consume green tea daily. A member of the holly family, yerba maté Ilex paraguariensis is a widely cultivated, medium-size evergreen tree indigenous to Paraguay, Brazil, and other South American countries.

The leaves are used as a stimulating tea. Maté bars are as prevalent in South America as coffee bars are in North America and Europe. Yerba maté is used in folk medicine as a diuretic; as a mild analgesic for headache and joint pains; as a laxative; for weight loss; and to treat heart conditions and depression.

It is traditionally considered a tonic or adaptogen. Yerba maté's primary active chemical constituents are caffeine 0. Maté leaves also contain antioxidant polyphenols, chlorophyll, vitamins, beta-carotene, niacin, pantothenic acid, vitamin C, minerals, and 15 amino acids.

Maté is thought to be safe when consumed in moderate amounts on a short-term basis. Like other caffeine-containing products, maté may cause insomnia, gastric irritation, nervousness, diuresis, and arrhythmias. No studies have evaluated the safety of yerba maté in children or in pregnant and lactating women.

Large amounts or prolonged use of maté are associated with an increased risk of cancer of the esophagus, mouth, larynx, kidney, bladder, and lung. Panax, or Asian ginseng, is one of the most popular herbs worldwide. Over six million people in the US use it because of its tonic or adaptogenic properties.

Use of the herb dates back to the Chinese Han dynasty, during which time it was referred to as the "root of heaven. Clinical applications include the treatment of fatigue, weakness, mild depression, cancer, hyperlipidemia, diabetes, impotence, hangovers, and menopause.

The German Commission E a German government–sponsored organization that evaluates herbs approved ginseng as a tonic for invigoration and fortification for fatigue and debility, for declining capacity for work and concentration, and for use during convalescence.

Ginseng contains a number of active constituents, including ginsenosides, a saponin, essential oils, phytosterols, and carbohydrates. Ginseng's mechanism of action is hypothesized to be a normalization of adrenal, thyroid, or pituitary hypothalamic adrenal axis function.

Studies evaluating ginseng's effect on stamina and well-being have suffered from poor design and inadequate numbers of subjects, and the results have been conflicting. Double-blind clinical control trials investigating the ergogenic and anti-fatigue effects of ginseng extract on physical and psychological performance also have had mixed results.

A number of early human studies found significant ergogenic effects with ginseng use among athletes, but these studies were small and poorly designed. More recent studies have not reproduced these results, and the overall evidence fails to demonstrate that ginseng has any direct impact on athletic performance.

Ginseng is usually well tolerated. The most common side effect is insomnia; less frequently reported side effects include vaginal bleeding, mastalgia, amenorrhea, palpitations, hypertension, hypotension, edema, anorexia, diarrhea, pruritus, headache, vertigo, and mania.

There are no long-term safety studies evaluating its use during pregnancy or lactation, or in infants or children.

Theoretically, ginseng interacts with warfarin and other medications that have anticoagulant and antiplatelet potential. In two case reports, ginseng apparently decreased the effectiveness of warfarin.

It may also lower the blood glucose level. There are 40 species of ephedra, the most popular of which are Ephedra sinica and Ephedra equisetina. Ephedra is known as Ma huang in traditional Chinese medicine TCM and is used to treat colds and flu, respiratory problems, fever, chills, headaches, allergic rhinitis, edema, and joint and bone pain, and as a diuretic.

In TCM, ephedra is usually combined with other herbs. An estimated 12 million people in the US have used products containing ephedra, 22 primarily for weight loss, athletic performance, energy enhancement, and, to a lesser extent, allergic disorders, nasal congestion, and respiratory conditions such as asthma.

Ephedra contains approximately 0. Ephedra's primary chemical constituent, ephedrine, was isolated in , and became a popular medication in the US during the s as a decongestant and bronchodilator. In the last quarter of the 20th century, ephedrine was used as a mainstream therapy for asthma and to correct hypotension resulting from spinal or epidural anesthesia.

Today, ephedrine is common in over-the-counter products Table 3. Among teenagers and young adults, ephedrine is known as "natural ecstasy. The stimulant activity of ephedrine is one-fifth as strong as amphetamine. Some athletes use ephedrine to boost their performance; ephedrine is banned by the International Olympic Committee, however.

Ephedrine and pseudoephedrine are both nonselective a- and ß-receptor agonists and can directly and indirectly stimulate the central nervous system. Ephedrine increases heart rate, blood pressure, and peripheral vasoconstriction; it also relaxes smooth muscle and causes bronchodilation.

Ephedrine has diuretic effects, but can exacerbate urinary retention. Most clinical studies have focused on the use of ephedrine as treatment for asthma or weight loss. Safer, more selective ß-agonist medications such as albuterol are now used in the treatment of asthma.

Trials of ephedrine or ephedrine-caffeine combinations have not shown consistent or dramatic results on weight loss, but have shown significant adverse effects.

Over cases of possible ephedra toxicity were reported to the Food and Drug Administration FDA from to , including 37 serious cardiovascular events, 11 sudden deaths, 16 strokes, and 10 heart attacks. Dosages typically used to treat allergic symptoms and asthma may lead to mild tachycardia, hypertension, insomnia, jitteriness and decreased appetite, dizziness, restlessness, anxiety, irritability, insomnia, headache, flushing, difficulty urinating, heart palpitations, and increased blood pressure.

Chronic use can result in dependence or tolerance. Patients with hypertension, heart problems, diabetes, depression, thyroid disease, anxiety disorders, insomnia, anorexia or bulimia, tremor, kidney stones, or urinary retention should be extremely cautious when considering taking ephedra.

Ephedra also has many drug interactions, and should be avoided by patients taking MAO-inhibiting antidepressants, CNS stimulants or cardiovascular stimulants for example, digoxin and cardiac glycosides , ß-blockers, methyldopa, decongestants, oral steroids, antidiabetic drugs, or halothane.

Combining ephedra with methylxanthines or caffeine-containing products or herbs may increase the risk of adverse effects. Ephedrine crosses the placenta and is found in breast milk, and can harm fetuses and infants.

It may also cause uterine stimulation. The safety of ephedra for the consumer is a hotly debated subject, and new information is being reviewed every day. Based on numerous reports of toxicity, in the FDA convened a special advisory committee on ephedrine-containing dietary supplements.

It proposed a policy that ephedrine-containing products must be properly labeled to list all possible adverse effects, including death, and contain a warning that the product not be used for longer than seven days. The FDA further proposed, among other things, prohibiting the marketing of dietary supplements containing 8 mg or more of ephedrine alkaloids per "serving"; a ban on labeling that recommends a total daily intake of 24 mg or more; and a ban on the combination of ephedra and caffeine in products.

However, the proposal was tabled after a hearing of the General Accounting Office at which the dietary supplement industry challenged the link between ephedra and serious side effects. They questioned the basic science behind the FDA dosing recommendations and how the FDA reviewed their adverse event reports.

Although the FDA has not implemented its restrictions on ephedra, 28 states have independently implemented varying restrictions. Ephedra is also banned in Canada and by the US National Collegiate Athletic Association. Four leading dietary supplement associations have banded together to create special labeling for ephedra products and are encouraging the FDA to adopt their labeling as a required national standard.

Both the FDA and the herbal industry have clearly come out against the use of ephedra as a recreational drug, such as in Herbal Ecstasy. The FDA has announced that ephedra products marketed as recreational drugs are unproved and misbranded drugs subject to seizure and injunction.

In February , two important events led the FDA to clamp down on ephedra and require warning labels on ephedra products. First, the death of Baltimore Orioles baseball pitching prospect Steve Bechler was linked to ephedra. Second, results of a RAND Corporation study to review ephedra, commissioned by the National Institutes of Health, provided additional evidence that ephedra may be associated with important health risks.

After the study was released, FDA Commissioner Mark B. McClellan, MD, PhD, noted: "We are particularly concerned about the risks of using products containing ephedra during heavy workouts, with caffeine and other stimulants, in a diet program that stresses the cardiovascular system, or by people under the age of We are also concerned about potential stresses to the body caused by the long-term use of ephedra.

To return to our cases: When discussing with the mother her frequent consumption of green tea, it is important to educate her that the caffeine in the green tea is passing through her breast milk, and that this could be responsible for her infant's irritability.

Next, we turn to the high school football team members' use of natural sport supplements. We would educate the team members of the dangers of ephedra's side effects and explain that ephedrine is banned in Olympic sports. Last, herbal weight loss supplements are very popular with adolescent girls, but they are a dangerous "quick fix.

More children and teenagers are exposed to herbal stimulants and are using them in daily activities. Because these compounds are easy to purchase and widely available, parents are not always aware of the stimulant products their children consume.

Insomnia, agitation, nervousness, and other common childhood problems could be side effects of an herbal stimulant. It is important that health-care providers routinely ask children about which supplements they are using and be aware of common side effects and risks.

The box "Nonprescription stimulants: Web sites of note" lists resources of evidence-based information about herbs and dietary supplements. Olfson M, Marcus SC, Weissman MM, et al: National trends in the use of psychotropic medications by children.

J Am Acad Child Adolesc Psychiatry ; Ellison R: Caffeine intake and salivary levels in children. Paper presented at the 7th International Caffeine Workshop, Greece, June Pollack CP, Bright D: Caffeine consumption and weekly sleep patterns in US seventh-, eighth-, and ninth-graders.

Pediatrics ; Castellanos FX, Rapoport JL: Effects of caffeine on development and behavior in infancy and childhood: A review of the published literature. Food Chem Toxicol ; Rapoport JL, Berg CJ, Ismond DR, et al: Behavioral effects of caffeine in children.

Relationship between dietary choice and effects of caffeine challenge. Archives of General Psychiatry ;41 11 Hughes JR, Hale KL: Behavioral effects of caffeine and other methylxanthines on children. Exp Clin Psychopharmacol ;6 1 Bernstein G: Caffeine effects on learning, performance, and anxiety in normal school-aged children.

Stein MA, Krasowski M, Leventhal BL, et al: Behavioral and cognitive effects of methylxanthines. A meta-analysis of theophylline and caffeine. Arch Pediatr Adolesc Med ; 3 Bernstein GA, Carroll ME, Dean NW, et al: Caffeine withdrawal in normal school-age children.

Mukhtar H, Wang ZY, Katiyar SK, et al: Tea components: Antimutagenic and anticarcinogenic effects. Prev Med ; Dulloo AG, Duret C, Rohrer D, et al: Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing h energy expenditure and fat oxidation in humans.

Am J Clin Nutr ;70 6 Merhav H, Amitai Y, Palti H, et al: Tea drinking and microcytic anemia in infants. Am J Clin Nutr ; 41 6 Mate Monograph, Natural Medicines Comprehensive Database, www.

com , accessed Nov. Blumenthal M: The Complete German Commission E Monographs , American Botanical Council, Texas, , pp Newall C: Herbal Medicines, A Guide for Health Care Professionals , The Pharmaceutical Press, London, , p Omantauna D: Ginseng to enhance sports performance.

Alt Med Alert ;4 7 Vogler BK, Pittler MH, Ernst E: The efficacy of ginseng: A systematic review of randomized clinical trials. European Journal Clinical Pharmacology ;55 8 : Cheng T: Ginseng warfarin interaction, ACC Current Journal Review ;9 1 Janetzky K: Probable interaction between warfarin and ginseng.

American Journal Health System Pharmacy ; Sotaniemi EA, Haapakoski E, Rautio A: Ginseng therapy in non-insulin dependent diabetic patient. Diabetes Care ;18 10 Haller C, Benowitz NL: Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids.

N Engl J Med ; Berman A: Ephedra for weight loss. Alternative Therapies in Women's Health. Samenuk D, Link MS, Homoud MK, et al: Adverse cardiovascular events temporally associated with ma huang, an herbal source of ephedrine.

Mayo Clin Proc 2 ;77 1 FDA News, US Food and Drug Administration: HHS acts to reduce potential risks of dietary supplements containing ephedra, Feb Paula Gardiner, Cora Collette Breuner, Kathi Kemper. What's the buzz? Contemporary Pediatrics August ; Community collaboration fails to boost parental awareness on HPV vaccination during primary care visits.

Despite efforts to enhance communication between clinics and community groups, a study finds no significant improvement in parental knowledge and attitudes toward HPV vaccination during children's primary care visits, highlighting the persistent challenge of low vaccine uptake in the United States.

Having "the talk" with teen patients. A visit with a pediatric clinician is an ideal time to ensure that a teenager knows the correct information, has the opportunity to make certain contraceptive choices, and instill the knowledge that the pediatric office is a safe place to come for help.

Dysmenorrhea history associated with endometriosis risk in adolescents. Around thirty plant species are known to contain caffeine. Other sources include the leaves of yaupon holly , South American holly yerba mate , and Amazonian holly guayusa ; and seeds from Amazonian maple guarana berries. Temperate climates around the world have produced unrelated caffeine-containing plants.

Caffeine in plants acts as a natural pesticide : it can paralyze and kill predator insects feeding on the plant. Firstly, in the cell vacuoles where it is complexed with polyphenols.

This caffeine probably is released into the mouth parts of insects, to discourage herbivory. Secondly, around the vascular bundles, where it probably inhibits pathogenic fungi from entering and colonizing the vascular bundles. The differing perceptions in the effects of ingesting beverages made from various plants containing caffeine could be explained by the fact that these beverages also contain varying mixtures of other methylxanthine alkaloids , including the cardiac stimulants theophylline and theobromine , and polyphenols that can form insoluble complexes with caffeine.

Products containing caffeine include coffee, tea, soft drinks "colas" , energy drinks , other beverages, chocolate , [] caffeine tablets, other oral products, and inhalation products.

According to a study in the United States, coffee is the major source of caffeine intake in middle-aged adults, while soft drinks and tea are the major sources in adolescents.

The world's primary source of caffeine is the coffee "bean" the seed of the coffee plant , from which coffee is brewed. Caffeine content in coffee varies widely depending on the type of coffee bean and the method of preparation used; [] even beans within a given bush can show variations in concentration.

In general, one serving of coffee ranges from 80 to milligrams, for a single shot 30 milliliters of arabica-variety espresso , to approximately — milligrams for a cup milliliters of drip coffee. Tea contains more caffeine than coffee by dry weight. A typical serving, however, contains much less, since less of the product is used as compared to an equivalent serving of coffee.

Also contributing to caffeine content are growing conditions, processing techniques, and other variables. Thus, teas contain varying amounts of caffeine.

Tea contains small amounts of theobromine and slightly higher levels of theophylline than coffee. Preparation and many other factors have a significant impact on tea, and color is a very poor indicator of caffeine content.

Teas like the pale Japanese green tea , gyokuro , for example, contain far more caffeine than much darker teas like lapsang souchong , which has very little. Caffeine is also a common ingredient of soft drinks , such as cola , originally prepared from kola nuts.

Soft drinks typically contain 0 to 55 milligrams of caffeine per 12 ounce mL serving. The caffeine in these drinks either originates from the ingredients used or is an additive derived from the product of decaffeination or from chemical synthesis.

Guarana, a prime ingredient of energy drinks, contains large amounts of caffeine with small amounts of theobromine and theophylline in a naturally occurring slow-release excipient. Chocolate derived from cocoa beans contains a small amount of caffeine. The weak stimulant effect of chocolate may be due to a combination of theobromine and theophylline, as well as caffeine.

By weight, dark chocolate has one to two times the amount of caffeine as coffee: 80— mg per g. Tablets offer several advantages over coffee, tea, and other caffeinated beverages, including convenience, known dosage, and avoidance of concomitant intake of sugar, acids, and fluids.

A use of caffeine in this form is said to improve mental alertness. One U. company is marketing oral dissolvable caffeine strips. Similar to an e-cigarette , a caffeine inhaler may be used to deliver caffeine or a stimulant like guarana by vaping.

According to Chinese legend, the Chinese emperor Shennong , reputed to have reigned in about BCE, inadvertently discovered tea when he noted that when certain leaves fell into boiling water, a fragrant and restorative drink resulted. The earliest credible evidence of either coffee drinking or knowledge of the coffee plant appears in the middle of the fifteenth century, in the Sufi monasteries of the Yemen in southern Arabia.

From the Middle East, coffee drinking spread to Italy, then to the rest of Europe, and coffee plants were transported by the Dutch to the East Indies and to the Americas. Kola nut use appears to have ancient origins. It is chewed in many West African cultures, in both private and social settings, to restore vitality and ease hunger pangs.

The earliest evidence of cocoa bean use comes from residue found in an ancient Mayan pot dated to BCE. Also, chocolate was consumed in a bitter and spicy drink called xocolatl , often seasoned with vanilla , chile pepper , and achiote.

Xocolatl was believed to fight fatigue, a belief probably attributable to the theobromine and caffeine content. Chocolate was an important luxury good throughout pre-Columbian Mesoamerica , and cocoa beans were often used as currency.

Xocolatl was introduced to Europe by the Spaniards , and became a popular beverage by The Spaniards also introduced the cacao tree into the West Indies [] and the Philippines. The leaves and stems of the yaupon holly Ilex vomitoria were used by Native Americans to brew a tea called asi or the " black drink ".

In , the German chemist Friedlieb Ferdinand Runge isolated relatively pure caffeine for the first time; he called it "Kaffebase" i.

Furthermore, Berzelius stated that the French chemists had made their discoveries independently of any knowledge of Runge's or each other's work. Pelletier's article on caffeine was the first to use the term in print in the French form Caféine from the French word for coffee: café.

Caffeine, noun feminine. Crystallizable substance discovered in coffee in by Mr. During the same period — while they were searching for quinine in coffee because coffee is considered by several doctors to be a medicine that reduces fevers and because coffee belongs to the same family as the cinchona [quinine] tree — on their part, Messrs.

Pelletier and Caventou obtained caffeine; but because their research had a different goal and because their research had not been finished, they left priority on this subject to Mr.

We do not know why Mr. Robiquet has not published the analysis of coffee which he read to the Pharmacy Society. Its publication would have allowed us to make caffeine better known and give us accurate ideas of coffee's composition Robiquet was one of the first to isolate and describe the properties of pure caffeine, [] whereas Pelletier was the first to perform an elemental analysis.

In , M. Oudry isolated "théine" from tea, [] but in it was proved by Mulder [] and by Carl Jobst [] that theine was actually the same as caffeine. In , German chemist Hermann Emil Fischer — first synthesized caffeine from its chemical components i.

a " total synthesis " , and two years later, he also derived the structural formula of the compound. Because it was recognized that coffee contained some compound that acted as a stimulant, first coffee and later also caffeine has sometimes been subject to regulation.

For example, in the 16th century Islamists in Mecca and in the Ottoman Empire made coffee illegal for some classes. In , caffeine became the focus of one of the earliest documented health scares, when the US government seized 40 barrels and 20 kegs of Coca-Cola syrup in Chattanooga, Tennessee , alleging the caffeine in its drink was "injurious to health".

Forty Barrels and Twenty Kegs of Coca-Cola , two bills were introduced to the U. House of Representatives in to amend the Pure Food and Drug Act , adding caffeine to the list of "habit-forming" and "deleterious" substances, which must be listed on a product's label.

The US Food and Drug Administration FDA considers safe beverages containing less than 0. However, there is no regulatory provision for mandatory quantitative labeling of caffeine, e. There are a number of food ingredients that naturally contain caffeine. These ingredients must appear in food ingredient lists.

However, as is the case for "food additive caffeine", there is no requirement to identify the quantitative amount of caffeine in composite foods containing ingredients that are natural sources of caffeine.

While coffee or chocolate are broadly recognized as caffeine sources, some ingredients e. For these natural sources of caffeine, there is no regulatory provision requiring that a food label identify the presence of caffeine nor state the amount of caffeine present in the food.

Global consumption of caffeine has been estimated at , tonnes per year, making it the world's most popular psychoactive substance. The Seventh-day Adventist Church asked for its members to "abstain from caffeinated drinks", but has removed this from baptismal vows while still recommending abstention as policy.

The Church of Jesus Christ of Latter-day Saints has said the following with regard to caffeinated beverages: " the Church revelation spelling out health practices Doctrine and Covenants 89 does not mention the use of caffeine. The Church's health guidelines prohibit alcoholic drinks, smoking or chewing of tobacco, and 'hot drinks' — taught by Church leaders to refer specifically to tea and coffee.

Gaudiya Vaishnavas generally also abstain from caffeine, because they believe it clouds the mind and overstimulates the senses. Caffeinated beverages are widely consumed by Muslims.

In the 16th century, some Muslim authorities made unsuccessful attempts to ban them as forbidden "intoxicating beverages" under Islamic dietary laws. The bacteria Pseudomonas putida CBB5 can live on pure caffeine and can cleave caffeine into carbon dioxide and ammonia.

Caffeine is toxic to birds [] and to dogs and cats, [] and has a pronounced adverse effect on mollusks , various insects, and spiders. Caffeine has been used to double chromosomes in haploid wheat. Nachdem Goethe mir seine größte Zufriedenheit sowol über die Erzählung des durch scheinbaren schwarzen Staar Geretteten, wie auch über das andere ausgesprochen, übergab er mir noch eine Schachtel mit Kaffeebohnen, die ein Grieche ihm als etwas Vorzügliches gesandt.

Er hatte recht; denn bald darauf entdeckte ich darin das, wegen seines großen Stickstoffgehaltes so berühmt gewordene Coffein. Caffeine-induced increases in performance have been observed in aerobic as well as anaerobic sports for reviews, see [26,30,31] Contents move to sidebar hide.

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Download as PDF Printable version. In other projects. Wikimedia Commons. Central nervous system stimulant. This article is about the stimulant drug. For other uses, see Caffeine disambiguation. US DailyMed : Caffeine. N06BC01 WHO D11AX26 WHO , V04CG30 WHO.

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Main article: Caffeine dependence. See also: Caffeine-induced anxiety disorder , caffeine-induced sleep disorder , and caffeinism. See also: Coffee § Health effects. This section needs expansion with: practical management of overdose, see PMID You can help by adding to it.

November See also: Caffeinated alcoholic drink. Postsynaptic density. Synaptic vesicle. Neurotransmitter transporter. Axon terminal. Synaptic cleft. Structure of a typical chemical synapse. Main article: Decaffeination. Main article: Caffeinated drink.

Main articles: History of chocolate , History of coffee , History of tea , and History of yerba mate. See also: Energy drink § Regulations. The examples and perspective in this section deal primarily with the United States and do not represent a worldwide view of the subject.

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See also: Effect of psychoactive drugs on animals. Goethe was so impressed with the demonstration that: Nachdem Goethe mir seine größte Zufriedenheit sowol über die Erzählung des durch scheinbaren schwarzen Staar Geretteten, wie auch über das andere ausgesprochen, übergab er mir noch eine Schachtel mit Kaffeebohnen, die ein Grieche ihm als etwas Vorzügliches gesandt.

He was right; for soon thereafter I discovered therein caffeine, which became so famous on account of its high nitrogen content. Archived from the original on 14 May Retrieved 16 November doi : PMID S2CID Typically, onset of symptoms occurred 12—24 h after abstinence, with peak intensity at 20—51 h, and for a duration of 2—9 days.

Journal of Caffeine Research. PMC February Pharmacological Reports. University of Alberta. Archived from the original on 4 May Retrieved 8 August Pharmacology of Caffeine. National Academies Press US.

Archived from the original on 28 September Retrieved 15 December Pubchem Compound. Retrieved 16 October Royal Society of Chemistry.

Experimental Melting Point: — °C Alfa Aesar °C Oxford University Chemical Safety Data °C LKT Labs [C] °C Jean-Claude Bradley Open Melting Point Dataset °C Jean-Claude Bradley Open Melting Point Dataset , , , , , , Brain Research.

Brain Research Reviews. Nutrition Reviews. Pharmacological Reviews. Journal of Alzheimer's Disease. Principles of Life 2 ed. Macmillan Learning. ISBN Journal of Medicinal Chemistry.

Encyclopedia of Food and Health. Elsevier Science. Retrieved 17 June The Most Important Chemical Compounds: A Reference Guide. Greenwood Press. March Bibcode : Sci Archived from the original on 3 March Retrieved 10 March Meredith H ed.

Australian Broadcasting Corporation. Archived from the original on 26 July Retrieved 15 January ISSN World Health Organization. October [April ]. Archived PDF from the original on 23 April Retrieved 23 December Risk Management and Healthcare Policy.

Cochrane Pregnancy and Childbirth Group June The Cochrane Database of Systematic Reviews. Obstetrics and Gynecology. In Sydor A, Brown RY eds. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience 2nd ed.

New York: McGraw-Hill Medical. Long-term caffeine use can lead to mild physical dependence. A withdrawal syndrome characterized by drowsiness, irritability, and headache typically lasts no longer than a day. True compulsive use of caffeine has not been documented.

American Psychiatric Publishing. Archived from the original PDF on 1 July Retrieved 10 July Substance use disorder in DSM-5 combines the DSM-IV categories of substance abuse and substance dependence into a single disorder measured on a continuum from mild to severe.

Additionally, the diagnosis of dependence caused much confusion. Most people link dependence with "addiction" when in fact dependence can be a normal body response to a substance.

DSM-5 will not include caffeine use disorder, although research shows that as little as two to three cups of coffee can trigger a withdrawal effect marked by tiredness or sleepiness. There is sufficient evidence to support this as a condition, however it is not yet clear to what extent it is a clinically significant disorder.

The Journal of Clinical Investigation. Journal of Food Science. EFSA Journal. Pediatric Pulmonology. Biology of the Neonate. May The New England Journal of Medicine. Archived from the original on 22 April Retrieved 19 September January The Journal of Physiology.

Journal of Perinatology. IUPHAR Guide to Pharmacology. The International Union of Basic and Clinical Pharmacology. Archived from the original on 14 February Retrieved 13 February August The American Journal of Medicine. The Clinical Respiratory Journal.

Welsh EJ ed. International Journal of Colorectal Disease. Expert Review of Neurotherapeutics. Journal of the American Academy of Child and Adolescent Psychiatry. Orthomolecular Psychiatry. Archived PDF from the original on 6 October Archived from the original PDF on 31 January Caffeine does not usually affect performance in learning and memory tasks, although caffeine may occasionally have facilitatory or inhibitory effects on memory and learning.

Caffeine facilitates learning in tasks in which information is presented passively; in tasks in which material is learned intentionally, caffeine has no effect. Caffeine facilitates performance in tasks involving working memory to a limited extent, but hinders performance in tasks that heavily depend on this, and caffeine appears to improve memory performance under suboptimal alertness.

Most studies, however, found improvements in reaction time. The ingestion of caffeine does not seem to affect long-term memory. Its indirect action on arousal, mood and concentration contributes in large part to its cognitive enhancing properties.

Human Sleep and Cognition Part II - Clinical and Applied Research. Progress in Brain Research. Ker K ed. Neuroscience and Biobehavioral Reviews. Quote: Caffeine-induced increases in performance have been observed in aerobic as well as anaerobic sports for reviews, see [26,30,31] Sports Medicine.

International Journal of Sport Nutrition and Exercise Metabolism. Archived from the original PDF on 14 November Primary Care. Amphetamines and caffeine are stimulants that increase alertness, improve focus, decrease reaction time, and delay fatigue, allowing for an increased intensity and duration of training The American Journal of Clinical Nutrition.

Archived from the original PDF on 15 February Journal of the International Society of Sports Nutrition. Medicine and Science in Sports and Exercise. European Journal of Sport Science. Archived PDF from the original on 5 March Retrieved 2 December Journal of Science and Medicine in Sport.

Health Canada. Archived from the original on 10 August Retrieved 24 August Food and Chemical Toxicology Systematic review. Journal of the American Academy of Child and Adolescent Psychiatry Review.

Food and Chemical Toxicology. Archived from the original on 27 July Frontiers in Psychiatry. The Addiction Casebook. American Psychiatric Pub.

Committee on Nutrition and the Council on Sports Medicine and Fitness June Archived from the original on 17 October Retrieved 3 August Archives of Gynecology and Obstetrics. Birth Defects Research Part B: Developmental and Reproductive Toxicology. BMC Medicine. Public Health Nutrition.

Reproductive Health. A review". Scandinavian Journal of Gastroenterology. Human Physiology: From Cells to Systems 1st Canadian ed. MedlinePlus, US National Library of Medicine. Archived from the original on 5 January Retrieved 2 January Journal of Human Nutrition and Dietetics.

Archived from the original PDF on 8 March Renal Physiol. The claim: caffeine causes dehydration". New York Times. Archived from the original on 3 September Exercise and Sport Sciences Reviews.

Advances in Psychiatric Treatment. Psychological Medicine. The Australian and New Zealand Journal of Psychiatry. In Tasman A, Kay J, Lieberman JA, First MB, Riba M eds. Table Substance Dependence".

In Hosák L, Hrdlička M, et al. Psychiatry and Pedopsychiatry. Prague: Karolinum Press. At a high dose, caffeine shows a euphoric effect.

In Koob GF, Le Moal M, Thompson RF eds. Encyclopedia of Behavioral Neuroscience. Therefore, caffeine and other adenosine antagonists, while weakly euphoria-like on their own, may potentiate the positive hedonic efficacy of acute drug intoxication and reduce the negative hedonic consequences of drug withdrawal.

Pharmacology for health professionals 3rd ed. Chatswood, N. In contrast to the amphetamines, caffeine does not cause euphoria, stereotyped behaviors or psychoses. Neuropsychopharmacology and Therapeutics.

However, in contrast to other psychoactive stimulants, such as amphetamine and cocaine, caffeine and the other methylxanthines do not produce euphoria, stereotyped behaviors or psychotic like symptoms in large doses.

Current Addiction Reports. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience 3rd ed. McGraw-Hill Education. True compulsive use of caffeine has not been documented, and, consequently, these drugs are not considered addictive.

Caffeine for youth? Time to act! Psychiatry Fourth ed. Testing for Abuse Liability of Drugs in Humans PDF. Rockville, MD: U. Department of Health and Human Services Public Health Service Alcohol, Drug Abuse, and Mental Health Administration National Institute on Drug Abuse.

Archived from the original PDF on 22 December Dialogues in Clinical Neuroscience. Principles of addiction comprehensive addictive behaviors and disorders 1st ed.

Elsevier Academic Press. Retrieved 11 July Astrid Nehlig and colleagues present evidence that in animals caffeine does not trigger metabolic increases or dopamine release in brain areas involved in reinforcement and reward. A single photon emission computed tomography SPECT assessment of brain activation in humans showed that caffeine activates regions involved in the control of vigilance, anxiety, and cardiovascular regulation but did not affect areas involved in reinforcement and reward.

Caffeine is not considered addictive, and in animals it does not trigger metabolic increases or dopamine release in brain areas involved in reinforcement and reward. these earlier data plus the present data reflect that caffeine at doses representing about two cups of coffee in one sitting does not activate the circuit of dependence and reward and especially not the main target area, the nucleus accumbens.

Therefore, caffeine appears to be different from drugs of dependence like cocaine, amphetamine, morphine, and nicotine, and does not fulfil the common criteria or the scientific definitions to be considered an addictive substance. Through these interactions, caffeine is able to directly potentiate dopamine neurotransmission, thereby modulating the rewarding and addicting properties of nervous system stimuli.

Karch's pathology of drug abuse 4th ed. Boca Raton: CRC Press. The suggestion has also been made that a caffeine dependence syndrome exists In one controlled study, dependence was diagnosed in 16 of 99 individuals who were evaluated.

The median daily caffeine consumption of this group was only mg per day Strain et al. Since this observation was first published, caffeine addiction has been added as an official diagnosis in ICDM 9.

This decision is disputed by many and is not supported by any convincing body of experimental evidence. Archived from the original on 2 November F15 Mental and behavioural disorders due to use of other stimulants, including caffeine The dependence syndrome may be present for a specific psychoactive substance e.

Diagnostic and statistical manual of mental disorders : DSM-5 5th ed. Washington [etc. Arlington, VA: American Psychiatric Association.

Archived from the original on 1 August Retrieved 18 November Johns Hopkins Medicine. Archived from the original on 23 May Retrieved 25 May British Liver Trust.

Archived from the original on 12 May Retrieved 12 May European Journal of Nutrition. Dose-response analysis suggested that incidence of T2DM decreased June American Journal of Epidemiology.

Graefe's Archive for Clinical and Experimental Ophthalmology. Desk reference to the diagnostic criteria from DSM Washington, DC: American Psychiatric Publishing.

OCLC Archived from the original on 23 February In Smith BD, Gupta U, Gupta BS eds. Caffeine and Activation Theory: Effects on Health and Behavior.

CRC Press. Retrieved 25 November Diagnostic and Statistical Manual of Mental Disorders Fifth ed. American Psychiatric Association. CiteSeerX hdl : Nursing Clinical tutorial. Journal of Molecular and Cellular Cardiology.

StatPearls [Internet] Mini-review. National Center for Biotechnology Information. Archived from the original on 2 March Retrieved 1 March The Journal of Clinical Pharmacology and the Journal of New Drugs. Archived from the original on 12 January Archived from the original on 25 January Retrieved 18 May Scandinavian Journal of Clinical and Laboratory Investigation.

The Independent. Archived from the original on 12 October Retrieved 13 October The Telegraph. Archived from the original on 11 October Archived from the original on 25 April Retrieved 28 November Human Psychopharmacology.

Drug and Alcohol Dependence. Experimental and Clinical Psychopharmacology. An update". Clinical Pharmacokinetics. December International Journal of Epidemiology. Annual Review of Medicine.

American Family Physician. Practical management of pain Fifth ed. Elsevier Health Sciences. April Archived from the original on 15 July Archived from the original on 20 March Retrieved 15 November Part 1: drugs interacting with receptors" PDF.

Archived from the original PDF on 15 November On the other hand, our 'ventral shell of the nucleus accumbens' very much overlaps with the striatal compartment World of Caffeine.

Archived from the original on 10 December Retrieved 19 December Cellular and Molecular Life Sciences. International Union of Basic and Clinical Pharmacology. Retrieved 2 November By targeting A1-A2A receptor heteromers in striatal glutamatergic terminals and A1 receptors in striatal dopaminergic terminals presynaptic brake , caffeine induces glutamate-dependent and glutamate-independent release of dopamine.

These presynaptic effects of caffeine are potentiated by the release of the postsynaptic brake imposed by antagonistic interactions in the striatal A2A-D2 and A1-D1 receptor heteromers.

July Proceedings of the National Academy of Sciences of the United States of America. Bibcode : PNAS.. Adenosine A2A receptor A2AR -dopamine D2 receptor D2R heteromers are key modulators of striatal neuronal function.

It has been suggested that the psychostimulant effects of caffeine depend on its ability to block an allosteric modulation within the A2AR-D2R heteromer, by which adenosine decreases the affinity and intrinsic efficacy of dopamine at the D2R.

The striatal A2A-D2 receptor heteromer constitutes an unequivocal main pharmacological target of caffeine and provides the main mechanisms by which caffeine potentiates the acute and long-term effects of prototypical psychostimulants.

The Journal of Allergy and Clinical Immunology. Archived from the original PDF on 25 February American Journal of Respiratory and Critical Care Medicine. Journal of Immunology. Toxicology Letters. International Journal of Molecular Sciences.

Handbook of Experimental Pharmacology. Pharmacology, Biochemistry, and Behavior. European Journal of Clinical Pharmacology. Ugeskrift for Laeger in Danish. ISRN Pharmacology. Medscape Multi-Drug Interaction Checker.

The Pharmacogenetics and Pharmacogenomics Knowledge Base. Archived from the original on 17 July Retrieved 25 October Inxight Drugs. Archived from the original on 24 August Indian J Ophthalmol.

Gibson G ed. PLOS Genetics. The Merck Index 12th ed. Brittain HG ed. Profiles of Drug Substances, Excipients, and Related Methodology. Academic Press. The Facts About Caffeine Drugs.

Benchmark Books NY. Organic Chemistry Pearls of Wisdom. Boston Medical Publishing Corp. Chemistry Department, East Stroudsburg University. Archived from the original PDF on 2 January The Enzyme Database.

This post explores naturwl safety of Stimulaant ingredients found sourcse foods, beverages, and dietary Stimulant from natural sources. Some stimulants have ergogenic effects, Stkmulant they can enhance performance. Stress management techniques for anger management can find stimulants in prescribed medications, foods, beverages, dietary supplements, and other human-made substances. In this post, we focus on ingredients found in foods, beverages, and dietary supplements that are thought to be stimulants, including:. You can find many of these ingredients in coffee, teas, energy drinks, soda pops, drink flavor enhancers, chocolate, and dietary supplements like caffeine pills.

Stimulant from natural sources -

It works to lower levels of excitability and hyperactivity. GABA may also help ease anxiety and stress. GABA supplements may help children and adults with ADHD who have symptoms of hyperactivity, impulsivity, and aggressiveness.

A study noted that GABA may help reduce these symptoms in children and adults with both ADHD and some mental health conditions. A study found that an extract from gingko biloba may help improve ADHD symptoms in children.

Twenty children were given the extract instead of ADHD medication for 3 to 5 weeks. All of the children showed improvements in test scores and had better overall quality of life. More research and dosage testing is needed before gingko biloba can be used as an Adderall alternative in children and adults.

The antioxidant Pycnogenol , a registered trademark brand name of French maritime pine bark extract, may improve circulation and help lower blood pressure.

Taking this supplement may lower oxidative stress and inflammation in the body, which may in turn, lower ADHD symptoms. Researchers are currently studying the role oxidative stress and inflammation play in triggering ADHD symptoms, but more research is needed to confirm this association.

A study found that Pycnogenol supplements helped to significantly reduce symptoms of hyperactivity in children with ADHD. It also improved attention, concentration, and hand-eye coordination over a 4-week period. Some supplements that contain a combination of herbs are sold as an alternative for people who need to take Adderall.

It may help you stay calm and focused without anxiety and irritability. People without ADHD can still have difficulty focusing or concentrating. Talk to your healthcare provider before you change your dosage or decide to stop taking Adderall.

Tell them about any side effects you have while taking this drug. If Adderall is not right for you, your healthcare provider may recommend other prescription medications for ADHD, which can include:. Some herbal supplements can cause side effects. Taking too many vitamins and minerals can be harmful for your body.

Also, dosage, ingredient, and source information on the bottle may not be completely accurate. If you or your child has ADHD, prescription medications can help reduce symptoms and improve everyday quality of life. Adderall is commonly prescribed to treat ADHD. Adderall can cause side effects and may not be right for everyone.

Some herbs, mineral, and vitamin supplements may be natural alternatives. Natural supplements can also cause side effects or interactions. Discuss their use with your healthcare provider before taking them. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Learn how the ADHD drugs Ritalin and Adderall compare to one another. Get the facts on dosage, how they work, who should avoid each drug, and more. Dexedrine and Adderall are two commonly prescribed ADHD drugs. But, even though they treat the same condition, they have important differences.

There may not be a current cure for ADHD, but several options can help manage symptoms. Learn about medications, therapies, and behavioral…. While they're not typically able to prescribe, nutritionists can still benefits your overall health.

Let's look at benefits, limitations, and more. A new study found that healthy lifestyle choices — including being physically active, eating well, avoiding smoking and limiting alcohol consumption —…. Carb counting is complicated. Take the quiz and test your knowledge!

Together with her husband, Kansas City Chiefs MVP quarterback Patrick Mahomes, Brittany Mohomes shares how she parents two children with severe food…. While there are many FDA-approved emulsifiers, European associations have marked them as being of possible concern.

Let's look deeper:. Researchers have found that a daily multivitamin supplement was linked with slowed cognitive aging and improved memory. A Quiz for Teens Are You a Workaholic?

How Well Do You Sleep? Health Conditions Discover Plan Connect. Are There Natural Alternatives to Adderall and Do They Work? Medically reviewed by Natalie Olsen, R. Share on Pinterest. A word of caution Natural supplements can cause side effects and may interact with other medications.

Was this helpful? Mineral supplements. Vitamin B-6 and magnesium. Ginkgo biloba. Healthline only shows you brands and products that we stand behind. It provides various health benefits but is particularly effective at lowering blood sugar levels 1. These effects are thought to be due to numerous mechanisms.

In particular, berberine is believed to reduce glucose production in your liver and improve insulin sensitivity 2 , 3. Studies show that taking berberine can lower blood sugar levels to a similar extent as the popular diabetes drug metformin 4. It lowers triglyceride and blood pressure levels, as well as total and LDL bad cholesterol, which may reduce your risk of heart disease 1 , 6 , 7 , 8.

Berberine has also been shown to have antibacterial effects and may protect against heart failure 9 , 10 , However, keep in mind that this substance is very powerful and has a range of biological effects.

Berberine is a powerful supplement. For example, it may help lower blood sugar levels and improve most major risk factors for heart disease. Turmeric contains curcumin, a powerful substance that has been studied thoroughly in recent years Curcumin fights inflammation at the molecular level by blocking an inflammatory signalling molecule called NF-kB 13 , For example, in a study in 45 people with rheumatoid arthritis, mg of curcumin per day was more effective than the anti-inflammatory drug diclofenac Curcumin also has numerous other health benefits.

According to one study, curcumin may also help fight depression. In fact, the results of this study found that curcumin performed as well as the antidepressant drug prozac These supplements are widely available in health stores and online. Curcumin is the biologically active agent in turmeric.

They inhibit the production of cholesterol in your liver, leading to significantly reduced blood cholesterol levels. Interestingly, an extract of a type of fermented rice called red yeast rice may have similar effects. It contains small amounts of monacolin K, which is the active ingredient in the statin drug Lovastatin Still, the amount of the active ingredient in supplements can vary up to fold depending on the brand Due to the potency of monacolin K, the Food and Drug Administration FDA has ruled that red yeast rice products containing this substance should be considered a drug rather than a supplement Some manufacturers try to evade these regulations by selling red yeast rice supplements that only contain trace amounts of monacolin K.

For this reason — and due to potential side effects — you should ask your healthcare provider to help you find a high-quality supplement from a reputable manufacturer.

It can reduce cholesterol levels and the risk of heart attacks and death in people who already have heart disease. Garlic is a popular ingredient in cuisines worldwide, but it has also been used as a medicinal plant for thousands of years, including by the Greeks and Romans The main effects of garlic are due to one of its active compounds, allicin, which is highly beneficial for heart health Even more importantly, aged garlic extract can significantly lower blood pressure, which is a major risk factor for heart attacks, strokes, kidney disease, and early death 33 , In people with elevated levels, garlic can lower systolic blood pressure the top number in a reading by 8.

In one study in people with high blood pressure, garlic tablets were even more effective than the blood-pressure-lowering drug atenolol Garlic also appears to boost immune function and fight the common cold. You can buy garlic supplements in stores and online. Supplements containing aged garlic extract are available as well.

Garlic has a wide range of biological effects. It can lower blood pressure, improve cholesterol levels, and help fight the common cold. Supplements, no matter how effective, can never replace a healthy lifestyle with real food , exercise, and good sleep.

If you have a medical condition or take any medications, consult with your healthcare provider before trying these substances. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Life can take a toll on your energy levels. Fortunately, these 11 vitamins and supplements can boost your energy levels when you need it most. Numerous herbs and plants have been used for centuries as natural remedies, but if you're interested in alternative medicine, it can be tricky to know….

Supplements that increase nitric oxide in the body are incredibly popular. Here are 5 benefits of nitric oxide supplements for health and performance.

Resveratrol is a plant compound found in red wine.

The stimulants Stlmulant patient is Cognitive function support won't necessarily be SStimulant her chart natkral "medication history. A breastfeeding mother of a baby boy Gratitude for food concerned that her natutal has trouble sleeping Gratitude for food seems "wired. She wants to know what effects, if any, green tea has on the infant's sleep. What do you say? As the physician for the local high school football team, you are pleased when several players tell you they've stopped using anabolic steroids. However, they've now switched to a natural sport supplement containing ephedra. What do you do? Normally used Stjmulant treat ffrom conditions, such as ADHD and narcolepsy, amphetamines naturally stimulate central nervous system processes. Stimjlant a wide Stimulant from natural sources Natural fat loss exercises synthetic Allergen cross-contamination do exist on the market, many people may be ingesting natural amphetamines without actually knowing it. Natural amphetamines are derived from different plant species and may be marketed as herbal supplements, according to the U. National Library of Medicine. Other types of natural amphetamines take the form of precursor compounds found in organic materials. As a group, amphetamines produce the same overall effect in terms of speeding up central nervous system functions, but different types of natural amphetamines may produce this effect in different ways.